ICAP
ANA Patterns-Cytoplasmic Patterns
Code Pattern Previous Nomenclature Description
AC-15
Cytoplasmic fibrillar linear
actin-like

This pattern is characterized by decorated cytoskeletal fibers, sometimes with small, discontinuous granular deposits. Typical staining show striated actin cables spanning the long axis of the cells. e.g. anti-actin, anti-non-muscle myosin.

AC-16
Cytoplasmic fibrillar filamentous
none

Staining of microtubules and intermediate filaments spreading from the nuclear rim. e.g. anti-cytokeratin, anti-vimentin, anti-tropomyosin.

AC-17
Cytoplasmic fibrillar segmental
None

Enhanced decoration of short segments, periodic dense bodies, along the stress fibers. e.g. anti-alpha-actinin, anti-vinculin.                        

AC-18
Cytoplasmic discrete dots/GW body-like
GW body, processing body, lysosome*

Staining of GW bodies in the cytoplasm of interphase cells with high numbers in late S/G2 cells. e.g. anti-GW182, anti-Su/Ago2.                        

AC-19
Cytoplasmic dense fine speckled
cytoplasmic homogeneous

The pattern appears cloudy, almost homogeneous throughout the cytoplasm. e.g. anti-PL-7.                        

AC-20
Cytoplasmic fine speckled
cytoplasmic speckled

Scattered small speckles in the cytoplasm mostly with homogeneous or dense fine speckled background. e.g. anti-Jo-1.                        

AC-21
Cytoplasmic reticular/AMA
mitochondria-like

Coarse granular filamentous staining extending throughout the cytoplasm. e.g. anti-mitochondrial antibodies.                        

AC-22
Polar/Golgi-like
none

Discontinuous speckled or granular perinuclear ribbon-like staining with polar distribution in the cytoplasm. e.g. anti-giantin, anti-golgin-245.                        

AC-23
Rods and rings
none

 Distinct rod and ring structures in the cytoplasm of interphase cells. Some smaller rods and rings also reported in the nucleus.                        

 
 

Online since 19 May 2015