|
Clinical Relevance
First level information About Clinical Relevance & List of Abbreviations |
▶ The AC-7 pattern has low positive predictive value for any disease (40, 41) ▶ Antigens primarily localized in the dots include p80-coilin and SMN complex; specific immunoassays for these autoantibodies are currently not commercially available (42, 43) |
| First level information references |
40. Onouchi
H, Muro Y, Tomita Y. Clinical features and IgG subclass distribution of
anti-p80 coilin antibodies. J Autoimmun 1999;13:225–32. 41. Fujimoto
M, Kikuchi K, Tamaki T, et al. Distribution of anti-p80-coilin
autoantibody in collagen diseases and various skin diseases. Br J
Dermatol 1997;137:916–20. 42. Andrade
LE, Chan EK, Raska I, et al. Human autoantibody to a novel protein of
the nuclear coiled body: immunological characterization and cDNA cloning
of p80-coilin. J Exp Med 1991;173:1407–19. 43. Satoh
M, Chan JY, Ross SJ, et al. Autoantibodies to survival of motor neuron
complex in patients with polymyositis: immunoprecipitation of D, E, F,
and G proteins without other components of small nuclear
ribonucleoproteins. Arthritis Rheum 2011;63:1972–8. |
| Second level information |
▶ Anti‐p80‐coilin antibodies may rarely occur in SLE, (localized linear) SSc, and SjS (15‐17) ▶ Isolated (without anti‐snRNPs) anti‐SMN antibodies are reported in patients with AIM or SSc‐AIM overlap syndrome (18) ▶ The specificity of antibodies to p80‐coilin and the SMN complex can be confirmed by Western blot, solid phase immunoassays using recombinant proteins and immunoprecipitation (15, 18, 19) Notes: Most reports describe autoantibodies directly binding to specific antigens (i.e. antigen‐specific immunoassays) and do not actually show clear correlations with the AC‐7 pattern as such; specific immunoassays for these autoantibodies are currently not commercially available. |
| Second level information references |
15. Andrade
LE, Chan EK, Raska I, et al. Human autoantibody to a novel protein of
the nuclear coiled body: immunological characterization and cDNA cloning
of p80‐coilin. J Exp Med 1991;173:1407‐19. 16. Fujimoto
M, Kikuchi K, Tamaki T, et al. Distribution of anti‐p80‐coilin
autoantibody in collagen diseases and various skin diseases. Br J
Dermatol 1997;137:916‐20. 17. Onouchi
H, Muro Y, Tomita Y. Clinical features and IgG subclass distribution of
anti‐p80 coilin antibodies. J Autoimmun 1999;13:225‐32. 18. Satoh
M, Chan JY, Ross SJ, et al. Autoantibodies to survival of motor neuron
(SMN) complex in patients with polymyositis – immunoprecipitation of
D‐EF‐G without other components of small nuclear ribonucleoproteins.
Arthritis Rheum 2011;63:1972‐8. 19. Amlani
A, Hazlewood GS, Hamilton L, et al. Autoantibodies to the survival of
motor neuron complex in a patient with necrotizing autoimmune myopathy.
Rheumatology 2018;57:199‐200. |
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